A recent study has found that the pathogen infects completely healthy people and can cause blindness in one day and flesh-eating infections, brain abscesses and death in just a few days. They have also found that the pathogen is also resistant to all antibiotics.
Thomas A. Russo led the research along with his colleagues at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. Russo and his team colleagues have now discovered several biomarkers that can accurately identify hypervirulent K. pneumonia, which is the cause of all major worries. Researchers called this “a major step forward” in developing a consensus definition of the hypervirulent strain and in designing international studies to reveal more about its epidemiology and clinical presentation.
“Presently, there is no commercially available test to accurately distinguish classical and hypervirulent strains,” said Russo. “This research provides a clear road map as to how a company can develop such a test for use in clinical laboratories. It’s sorely needed,” he added.
He also added that a definitive diagnostic test would not only optimize patient care but would also allow researchers to perform epidemiologic surveillance to track how frequently the hypervirulent strain causes infection and how frequently it acquires antimicrobial resistance. While the assumption is that the pathogen spreads from person to person through food and water, the mode of transmission is still unknown.
Researchers explained that both strains of K. pneumoniae can be deadly, but the classical strain is more likely to infect patients with underlying disease, or who are immune-compromised and hospitalized.
By contrast, the hypervirulent strain can infect healthy, young people in the community, causing sudden, life-threatening complications, ranging from liver or brain abscesses to flesh-eating infections. While it’s currently less likely to be antibiotic resistant, these strains continue to evolve. Classical strains are more likely to be antimicrobial resistant. Read: ‘Eye ailment major problem amongst Indian children’
“What’s increasingly concerning is the growing number of reports that describe strains of hypervirulent K. pneumoniae that are antimicrobial resistant,” said Russo. “A bug that’s both hypervirulent and challenging to treat is a bad combination,” he further pointed out. An antimicrobial-resistant hypervirulent strain can develop in one of two ways, either by acquiring antimicrobial-resistance genes, or when an antimicrobial-resistant classical strain acquires hypervirulence.
“The latter mechanism is what caused the deaths of five patients in the intensive care unit of a hospital in Hangzhou, China, which was reported early this year,” Russo said. Read: Natural lipid may act as potent anti-inflammatory, says study
Since clinical laboratories have no test to detect the hypervirulent strain, it’s difficult, if not impossible, to properly diagnose it.
The so-called string test, currently used in some cases to distinguish the classical and hypervirulent strains, is not consistently accurate.
It’s especially problematic, Russo said, in North America and Europe, where there is a low prevalence of the hypervirulent strain.
“Many clinicians are unaware of the hypervirulent strain. And because there’s no diagnostic test, the clinical lab can’t give them a heads up,” said Russo.
Russo and his co-authors knew that the hypervirulence of K. pneumoniae is largely due to genes located on a large virulence plasmid, DNA that is independent from the chromosome. They hypothesized that some of these genes, including those producing iron-acqusition molecules called siderophores, might be good biomarkers. This proved to be the case.
They also found that higher concentrations of siderophores predicted hypervirulence. They then validated the identified biomarkers in a mouse infection model.
“The advantage of identifying these genetic biomarkers is that they can be developed into rapid nucleic acid tests, and if approved by the Food and Drug Administration, would then provide clinicians with an accurate method to quickly determine if a patient is suffering from an infection due to the classical or hypervirulent strain,” Russo explained.
He added that such a test will not only benefit patients and possibly save lives, but will also prove critical in learning more about hypervirulent K. pneumoniae.
“For example, we don’t know the frequency of infection by hypervirulent K. pneumoniae in different parts of the world,” he said.
“We know it infects all ethnic groups, but so far it’s been described most often in Asians, particularly in Asian Pacific Rim countries. Is that because hypervirulent K. pneumoniae is more commonly acquired in that part of the world but doesn’t necessarily result in infection, or because some Asian populations are, for some reason, more susceptible to it? Now we can begin to study those kinds of epidemiological questions,” said an inquisitive Russo.
The study appears in Journal of Clinical Microbiology.
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Published: July 8, 2018 12:19 pm