ناقص ٹوائلٹ حفظان صحت ، کھانا نہیں ، سپر بگ پھیلاؤ کے پیچھے: مطالعہ – انڈیا ٹوڈے

ناقص ٹوائلٹ حفظان صحت ، کھانا نہیں ، سپر بگ پھیلاؤ کے پیچھے: مطالعہ – انڈیا ٹوڈے


Translating…

Poor toilet hygiene, rather than undercooked chicken or other food, may be behind the spread of antibiotic-resistant E coli bacteria, a study has found. People harmlessly carry E coli bacteria in their gut, as do animals. However, some strains cause food poisoning whereas others cause urinary tract infections (UTIs), and infections after gut surgery, according to the researchers from the University of East Anglia (UEA) in the UK.

Antibiotic-resistant E coli different in humans and meat sources

E coli has become considerably more antibiotic resistant over the past 20 years both in humans and animals, the researchers said.

Particularly important are strains with ‘Extended Spectrum Beta-Lactamases (ESBLs) — enzymes that destroy many important penicillin and cephalosporin antibiotics, they said.

However, until now, it has not been known whether antibiotic-resistant E coli that cause bloodstream infections are picked up via the food chain, or passed from person to person.

Researchers showed how they sequenced the genomes of resistant E coli from multiple sources across the UK — including from human bloodstream infections, human faeces, human sewerage, animal slurry and meat including beef, pork and chicken, and fruit and salad.

The findings, published in The Lancet Infectious Diseases journal, show that antibiotic-resistant ‘superbug’ strains of E coli from human blood, faeces and sewerage samples were similar to one another.

Strain ‘ST131’ dominated among ESBL-E coli from all these human sample types, the researchers said.

They found that resistant E coli strains from meat, principally chicken, cattle and animal slurry were largely different to those infecting humans.

ST131 was scarcely seen. Instead, strains ST23, 117 and ST602 dominated, according to the researchers.

They found there was little crossover of ESBL-E coli from animals to humans.

How did researchers carry out the study?

The researchers looked at more than 20,000 faecal samples and around nine per cent were positive for ESBL-E coli across the regions, except for in London, where the carriage rate was almost double — at 17 per cent.

“We found ESBL-E coli in 65 per cent of retail chicken samples — ranging from just over 40 per cent in Scotland to over 80 per cent in Northwest England,” said David Livermore, from UEA’s Norwich Medical School.

“But the strains of resistant E coli, were almost entirely different from the types found in human faeces, sewage and bloodstream infections,” Livermore said.

“Only a very few beef and pork samples tested positive, and we didn’t detect ESBL-E coli at all in 400 fruit and vegetable samples — many of which were imported to the UK,” he said.

Study shows there are human-adapted and animal-adapted E coli strains but little crossover

The results show that there are human-adapted strains of ESBL-E coli, principally ST131, which dwell in the gut and which occasionally — usually via UTIs — go on to cause serious infections.

They study also shows that there are animal strains of ESBL-E coli.

“But — and critically — there’s little crossover between strains from humans, chickens and cattle. The great majority of strains of ESBL-E coli causing human infections aren’t coming from eating chicken, or anything else in the food chain,” David added.

Read: ‘Superbug gene’ on the move: First found in Delhi, has now reached the Arctic

Read: India’s first recorded presence of ‘super bug’

Read: 425-million -year-old bacteria living in guts of water animals formed antibiotic-resistant superbugs

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